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KMID : 1132720140120040216
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Genomics & Informatics
2014 Volume.12 No. 4 p.216 ~ p.224
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Relevance Epistasis Network of Gastritis for Intra-chromosomes in the Korea Associated Resource (KARE) Cohort Study
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Jeong Hyun-Hwan
Sohn Kyung-Ah
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Abstract
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Gastritis is a common but a serious disease with a potential risk of developing carcinoma. Helicobacter pylori infection is reported as the most common cause of gastritis, but other genetic and genomic factors exist, especially single-nucleotide polymorphisms (SNPs). Association studies between SNPs and gastritis disease are important, but results on epistatic interactions from multiple SNPs are rarely found in previous genome-wide association (GWA) studies. In this study, we performed computational GWA case-control studies for gastritis in Korea Associated Resource (KARE) data. By transforming the resulting SNP epistasis network into a gene-gene epistasis network, we also identified potential gene-gene interaction factors that affect the susceptibility to gastritis.
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KEYWORD
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gastritis, genome-wide association study, KARE, mutual information, relevance network, single-nucleotide polymorphism
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